Natural Factors EstroSense formula (also known as Breast Health formula in Canada) is for women of all ages who want healthy breasts and want to reduce their risk of breast cancer. This formula has been recommended to help prevent breast cancer and as part of a comprehensive protocol for the treatment of breast cancer. It is also indicated for fibrocystic breast syndrome and for women currently on hormone replacement therapy. Each ingredient contributes an important component to total breast health. The protective phytochemicals in the formula are standardized extracts, ensuring consistency and potency. Unlike isolated pharmaceuticals, these extracts are found in the base of the whole plant.
D-glucarate helps the body remove toxins, including carcinogens and excess estrogen. Not only does D-glucarate help to render toxins harmless in the liver, it also prevents this process from being reversed. An enzyme called beta-glucuronidase can change the harmless molecule back into a harmful toxin before it can be excreted. A related compound called D-glucaro-1,4-lactone (GL), inhibits the activity of beta-glucuronidase, allowing the toxins to be eliminated. "Oral ingestion of calcium D-glucarate has been shown to inhibit beta-glucuronidase. This means the body is better able to get rid of carcinogens and waste products. In one animal study, a single dose of calcium D-glucarate inhibited beta-glucuronidase activity by 57 percent in the blood, 44 percent in the liver, 39 percent in the intestines and 37% in the lungs. In the same study, beta-glucuronidase activity in the microflora was inhibited by 70 percent in the small intestine and by 54 percent in the colon. Calcium D-glucarate has the greatest potential as a compound against carcinogens for a number of reasons: (1) It is nontoxic when orally administered; (2) it is converted to the active GL form in the body, which inhibits beta-glucuronidase; and (3) it provides for the slow release of GL after ingestion."
Although human studies on Calcium D-glucarate are just beginning, animal studies show that it can inhibit breast, colon, lung, liver, skin and urinary bladder cancers. Excess circulating estrogens are also implicated in breast cancer. D-glucarate reduced estrogen and progesterone receptor levels in rats that had chemically-induced breast cancers.
Rosemary: Rosemary has powerful cancer-fighting properties and it contains potent antioxidants and other compounds that can prevent or block cancer formation. In one study, rats with a likelihood of developing mammary tumors were given rosemary extract. The rosemary extract resulted in a 47 percent decrease in mammary tumor formation compared to controls. Rats given rosemary (as one percent of their diet) two weeks prior to tumor-causing DMBA administration had 76 percent less of the carcinogen bind to their DNA than the rats fed a control diet. Tissue culture experiments on human liver and bronchial cells show that rosemary extract provides dual protection: It may increase liver enzymes that deactivate carcinogens and reduce the enzymes that enhance carcinogen formation.
Cruciferous family—Indole-3-carbinol and sulforaphane: Broccoli, cauliflower, cabbage, Brussels sprouts, kale--these vegetables are loaded with indoles and sulforaphane, powerful cancer-fighting chemicals. Indoles activate detoxification enzymes in the intestinal tract, bind to chemical carcinogens, rendering them inactive, and improve estrogen balance, reducing the risk of breast cancer. Indole-3-carbinol helps in the breakdown of estrogen into "good" metabolites and less of the "bad" estrogen metabolites.
Animal studies show that sulforaphane (a naturally occurring isothiocyanate) is also an effective cancer fighter. In particular sulforaphane helps with Phase II detoxification (Calcium D-glucarate also enhances this detoxification process). These enzymes neutralize dangerous carcinogens before they can damage DNA and promote cancer.
Silymarin--the active ingredient in Milk Thistle: The active ingredients in milk thistle are flavonoids comprised of silybin, silydianin and silychristin--collectively known as silymarin. Researchers are giving these flavonoids rave reviews for their ability to support liver function. A healthy liver improves our estrogen balance by metabolizing estrogen properly. The silymarin component is a powerful antioxidant and free radical scavenger and it also helps to increase glutathione, an antioxidant that can detoxify a wide range of hormones, drugs and toxins.